Annie Landesberg (with Button's play) is a girl who is unhappy with her life and wants to improve her relationships with her mother and sister. On the other hand, a boy named Owen Melargim (played by Jona Hill), son of a very rich New York family, is suffering from schizophrenia. Both of them are frustrated and tired of life. Until a man named Dr. Mantelerie who claims to have invented pills to solve all the problems, he asks people to join him for a few days. Annie and Owen, along with 10 others, are taking part in this experiment to test the pills for their treatment.